Treatment with Aida lotion reversed these changes by downregulating CPT1A, FABP5, MAP2K3, MAP2K1, and HRAS, and upregulating CYP27A1, thereby alleviating dermatitis symptoms and reducing inflammatory and mast cell infiltration.<h4>Discussion</h4>These findings identify CYP27A1, CPT1A, FABP5, MAP2K3, MAP2K1, and HRAS are prominent molecular signatures of atopic dermatitis in the antecubital and popliteal fossae. Here, MAP2K1 is linked to atopic eczema.