Treatment with Aida lotion reversed these changes by downregulating CPT1A, FABP5, MAP2K3, MAP2K1, and HRAS, and upregulating CYP27A1, thereby alleviating dermatitis symptoms and reducing inflammatory and mast cell infiltration.<h4>Discussion</h4>These findings identify CYP27A1, CPT1A, FABP5, MAP2K3, MAP2K1, and HRAS are prominent molecular signatures of atopic dermatitis in the antecubital and popliteal fossae. This evidence concerns the gene MAP2K1 and skin disorder.