Cytokine profiling revealed a tumor-promoting, myeloid-dominant inflammatory milieu in K18-hACE2<sup>TG</sup> mice, in contrast to a T cell-inflamed, anti-tumor profile in K18-hACE2<sup>TG</sup>/<i>Tymp<sup>-/-</sup></i> mice. The gene discussed is KRT18; the disease is neoplasm.