Disease activity [the bath ankylosing spondylitis disease activity index (BASDAI), the ankylosing spondylitis disease activity score calculated with C-reactive protein (ASDAS-CRP)], functional status [the bath ankylosing spondylitis functional index (BASFI)], back pain visual analog scale (VAS), inflammatory markers [CRP, erythrocyte sedimentation rate (ESR)], and adverse events were assessed at baseline and month 6. This evidence concerns the gene CRP and ankylosing spondylitis.