This study aims to analyze the functions of ARHGAP44 gene in a broad spectrum of human cancers, thus aiding in the better understanding of the collaborative network of cytoskeleton-related genes in cancers.<h4>Methods</h4>The study started with the analysis of the genetic characteristics of ARHGAP44 gene, followed by its expression patterns, frequent alterations as well as survival prediction value in a broad spectrum of human cancers. The gene discussed is ARHGAP44; the disease is cancer.