2) Clonal Evolution Pattern: The molecular profile evolved from typical MPN driver mutations (<i>JAK2</i>, <i>ASXL1</i>) to the acquisition of additional mutations associated with leukemic transformation (<i>NRAS</i>, <i>EZH2</i>, <i>TET2</i>), providing a concrete example for understanding the genetic mechanisms underlying such transformations. The gene discussed is JAK2; the disease is myeloproliferative neoplasm.