Therefore, this study aimed to compare the predictive ability of habitat models and conventional whole-tumor models for HER2 expression status in young breast cancer patients using multiparametric MRI.<h4>Methods</h4>A retrospective cohort consisting of 375 young breast cancer patients (age < 40 years) who underwent preoperative MRI scanning at two medical centers was included in this study. The gene discussed is ERBB2; the disease is breast cancer.