In multivariable analysis, elevated triglycerides and fasting glycemia were the strongest independent correlates of MS, while the <i>HIF-1α</i> rs11549465 CT+TT genotype remained independently associated with lower odds of MS (<i>p</i> < 0.05).<h4>Conclusion</h4>The <i>HIF-1α</i> rs11549465 T allele and CT+TT genotypes are associated with a lower odds of prevalent MS and hypertension in PLWH receiving ART. Here, HIF1A is linked to myeloid sarcoma.