Importantly, overexpression of RCN2 in the hippocampus was found to partially rescue cognitive decline, demonstrating its therapeutic potential for Alzheimer's disease in a diabetic mouse model.<h4>Conclusion</h4>The findings suggest that RCN2 is a key neuroprotective protein, and targeting RCN2 could represent a promising therapeutic strategy for neurodegenerative diseases like Alzheimer's, particularly in the context of diabetes. This evidence concerns the gene RCN2 and neurodegenerative disease.