<h4>Purpose</h4>To investigate the underlying mechanism linking diabetes to an increased risk of Alzheimer's disease (AD), specifically by examining the role of reticulocalbin-2 (RCN2) in the hippocampus.<h4>Methods</h4>Diabetes-associated cognitive impairment was examined using db/db mice on a C57BL/6J background. The gene discussed is RCN2; the disease is Alzheimer disease.