METHODS: In this individual patient data meta-analysis of 2 randomized controlled trials (performed 2000–2001 and 2002–2005), we investigated the impact of TGC with insulin (targeting blood glucose 80–110 mg/dL) in comparison with tolerating hyperglycemia to 215 mg/dL (liberal glucose control [LGC]) on atrial fibrillation in mixed surgical (n = 1548) and medical (n = 1200) ICU patients admitted to a quaternary-care university hospital. The gene discussed is INS; the disease is atrial fibrillation.