The prognostic roles of VDR polymorphisms, particularly rs7975232 (ApaI), rs1544410 (BsmI), rs2228570 / rs10735810 (FokI), and rs731236 (TaqI) with CRC outcomes, including CRC-specific survival, OS, and DFS were reported across 18 studies. The gene discussed is VDR; the disease is colorectal carcinoma.