The network pharmacological annotations revealed several pathways that are directly or indirectly affecting bone development, biomineralisation, calcium signalling, endochondral ossification with skeletal dysplasia, RANK signalling, RUNX2 regulation, and Vitamin D-sensitive Ca signalling.<h4>Conclusion</h4>This study systematically documents traditional treatments for bone fractures in Sikkim, highlighting 32 medicinal plants with therapeutic potential. The gene discussed is TNFRSF11A; the disease is skeletal dysplasia.