SOD1 and sporadic amyotrophic lateral sclerosis: <h4>Objective</h4>To explore the dynamic changes in excitability and viability of induced pluripotent stem cells (iPSC)-derived motor neurons from sporadic amyotrophic lateral sclerosis (ALS) and compare them with <i>SOD1</i>-related ALS patients and healthy control.<h4>Methods</h4>Peripheral blood samples were collected from ALS patients and healthy controls (HC) to establish the iPSC-derived motor neurons (MNs).