In contrast, <i>MAPK3</i> exhibited divergent trends, showing downregulation in tumor epithelial cells but significant upregulation in myeloid cells.<h4>Conclusion</h4><i>Enterococcus</i> exhibits a dual role in colitis-associated CRC, correlating with both tumor-suppressing and tumor-promoting effects. The gene discussed is MAPK3; the disease is colorectal carcinoma.