In particular, <i>IL10, IL11, CXCL10, IL1B,</i> and <i>IFNG</i> are protective genes in CRC; and there are four MAGs associated with CRC PFS, and they are all survival-risk genes: <i>COMT, PRL, EDNRA,</i> and <i>MAPK3</i>. The gene discussed is MAPK3; the disease is colorectal carcinoma.