This study aimed to analyze the clinical phenotypes and genetic variants in a family with hypofibrinogenemia and explore its molecular pathogenic mechanisms.<h4>Methods</h4>Fibrinogen (Fg) activity (Fg:C) was measured using the Clauss method and the prothrombin time (PT)-derived method, and Fg antigen (Fg:Ag) levels were determined by enzyme-linked immunosorbent assay (ELISA). Here, F2 is linked to Hypofibrinogenemia.