This study aims to elucidate the cellular landscape and GSH metabolic features of the GBM microenvironment and to clarify the role of GSH S-transferase alpha 4 (GSTA4) in GBM progression.<h4>Methods</h4>ScRNA-seq was performed on 104,789 GBM cells to systematically identify cell subpopulations and construct cell interaction networks. The gene discussed is GSTA4; the disease is glioblastoma.