We report a 65-year-old man with <i>FLT3</i> D835V-mutated acute myeloid leukemia (AML) and <i>BCR::ABL1</i>-positive chronic myeloid leukemia (CML) that coexisted as genetically independent clones. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.