Potential disease specific proteins included fructose-bisphosphate aldolase A (ALDOA), L-lactate dehydrogenase A chain (LDHA), malate dehydrogenase, cytoplasmic (MDH1), and phosphoglycerate mutase 1 (PGAM1), which were upregulated in AD and MCI Aβ+ across multiple cohorts and did not display altered levels in DLB and FTD. Here, MDH1 is linked to frontotemporal dementia.