Functional assays, including ESRP2 knockdown and overexpression, were conducted to assess its impact on EMT marker expression, cellular behavior, and stemness-related features such as clonogenicity, spheroid formation, and cell surface marker expression.<h4>Results</h4>High ESRP2 expression correlated with improved patient survival and an epithelial-like phenotype in BC models. This evidence concerns the gene ESRP2 and breast cancer.