This study aimed to investigate the clinical significance and mechanistic role of epithelial splicing regulatory protein 2 (ESRP2) in BC.<h4>Methods</h4>Integrative analyses of publicly available transcriptomic datasets (TCGA and GEO) were performed to evaluate the prognostic value of ESRP2 and its association with epithelial and mesenchymal phenotypes in BC cell lines. This evidence concerns the gene ESRP2 and breast cancer.