Expression of <i>RAX</i> was not reliably detectable.<h4>Conclusion</h4>This study identified <i>TMEM150B</i>, <i>TNIP1</i>, <i>ATRN</i>, <i>FAAH</i>, <i>FBXW4</i> and <i>WNT8B</i> as key genes in the development of HL through inflammatory response and Wnt signaling pathways, providing new theoretical insights into therapeutic mechanisms. Here, WNT8B is linked to Hodgkins lymphoma.