This study aims to evaluate the higher prevalence and potential role of <i>MTHFR</i> gene polymorphisms (C677T and A1298C) in the etiology of recurrent spontaneous miscarriages in pregnant women with inherited thrombophilia, in comparison with the classical thrombophilia-associated SNPs-<i>F5</i> Leiden and the <i>F2 G20210A</i> gene mutation. This evidence concerns the gene MTHFR and thrombophilia.