In multivariable analysis, ACR remained independently associated with the endpoint in Model 1 (ACR + prior HF hospitalization: OR 4.21, 95% CI 1.93-9.17; <i>p</i> < 0.001) and Model 2 (additional adjustment for log<sub>10</sub> NT-proBNP: OR 3.49, 95% CI 1.54-7.91; <i>p</i> = 0.003). This evidence concerns the gene NPPB and hydrops fetalis.