Strong negative correlations were observed between the ApoA2 index and both the miRNA model index (r = -0.62) and the miRNA+CA19-9 index (r = -0.63).<h4>Conclusions</h4>These findings suggest that miRNA-based diagnostic models, particularly when combined with CA19-9, could serve as powerful tools for the early detection of pancreatic cancer. This evidence concerns the gene APOA2 and familial pancreatic carcinoma.