<b>Results:</b> Clinical analysis of 43 pairs of HNSCC tumor and adjacent normal tissues revealed that elevated CAV2 expression was significantly associated with poor prognosis in HNSCC patients (95%CI: 1.197-1.7518, <i>p</i> = 1.33 × 10<sup>-13</sup>). The gene discussed is CAV2; the disease is head and neck squamous cell carcinoma.