The specific aims of this study were: (a) to investigate the effect of cannabinoid acids on the release of glial neuroinflammatory mediators, (b) to examine the effect of intraperitoneally administered cannabinoid acids on symptoms of MS, and (c) to evaluate their effects on microglial and astrocyte activation and CD4<sup>+</sup> T cell infiltration into the spinal cords of MS mice. This evidence concerns the gene CD4 and myeloid sarcoma.