Van Maldergem Syndrome (VMS) is a rare autosomal recessive disorder caused by pathogenic variants in the atypical cadherin genes <i>DCHS1</i> or <i>FAT4</i> and is marked by craniofacial, skeletal, and neurodevelopmental abnormalities. The gene discussed is CDH17; the disease is Cerebro-facio-articular syndrome.