In parallel, DCs were cocultured with naïve CD4<sup>+</sup> T cells in the presence of Hyper-IL-6 (an IL-6/sIL-6R fusion protein that activates IL-6 <i>trans</i>-signaling) with or without sgp130 to quantify DC-derived IL-23 and Th17 differentiation; additionally, DCs conditioned with Hyper-IL-6 with or without sgp130 were delivered intratracheally to establish a DC-transfer asthma model. The gene discussed is IL6ST; the disease is asthma.