<h4>Objectives</h4>To evaluate the association between biomarkers related to intestinal epithelial barrier integrity, systemic inflammation, and clinical response to anti-TNF therapy in patients with rheumatoid arthritis (RA).<h4>Methods</h4>A prospective controlled 24-week study of patients with active RA receiving anti-TNF therapy was performed. The gene discussed is TNF; the disease is rheumatoid arthritis.