This study aims to investigate the role of circRNA_0021727 in ECRS-related inflammation, as well as the regulatory interactions among circRNA_0021727, miRNA_145_5p, and ADAM12 in ECRS.<h4>Methods</h4>Primary nasal epithelial cells (PNECs) were isolated from nasal polyp tissues of 10 ECRS patients and inferior turbinate tissues of 10 nasal septum deviation patients for differential expression analysis. This evidence concerns the gene ADAM12 and Nasal polyposis.