ADAM12 and Nasal Septal Perforation: This study aims to investigate the role of circRNA_0021727 in ECRS-related inflammation, as well as the regulatory interactions among circRNA_0021727, miRNA_145_5p, and ADAM12 in ECRS.<h4>Methods</h4>Primary nasal epithelial cells (PNECs) were isolated from nasal polyp tissues of 10 ECRS patients and inferior turbinate tissues of 10 nasal septum deviation patients for differential expression analysis.