As a proof of concept, we applied DuAL-Net to 14,094 SNPs within the <i>APOE</i> ±50-kb region from 1,050 individuals in the Alzheimer's Disease Neuroimaging Initiative and Alzheimer's Disease Sequencing Project (ADSP) cohorts. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.