These differences remained statistically significant after adjustment for age, sex, body mass index, Model for End-Stage Liver Disease-Sodium score and C-reactive protein.<h4>Conclusion</h4>The attenuated IE is associated with the severity of glucose intolerance, and the development of DM is associated with a blunted GIP secretory response in patients with HBV-ACLF. Here, CRP is linked to Glucose intolerance.