TGM4 and ankylosing spondylitis: However, little is currently known about the efficacy and safety of TGP therapy for treating AS.<h4>Purpose</h4>This study aimed to provide evidence-based support for the efficacy and safety of TGP in treating ankylosing spondylitis and to explore the potential mechanisms underlying TGP therapy for this disease.<h4>Methods</h4>A search strategy combining keywords and free-text terms was employed to retrieve studies from eight databases: CBM, CNKI, VIP, Wanfang, Embase, PubMed, Cochrane Library, and Web of Science.