Consistent with this, the recessive model (TT vs. CC + CT) also indicated that the TT genotype conferred a higher risk (OR = 2.27); for rs1800682 locus, the increased risks of NIHL were associated with G allele compared with A allele, the risk of NIHL was 2.81-fold higher in individuals with the GG genotype compared with those with the AA genotype.<h4>Conclusion</h4>T allele at rs1468063 and G allele at rs1800682 of FAS gene were independently associated with the increased risk for NIHL, and these alleles may be potential biomarkers for early identification and risk stratification to NIHL. This evidence concerns the gene FAS and noise induced hearing loss.