This study aims to explore and verify the relationship between FAS gene polymorphisms and NIHL susceptibility.<h4>Subjects and methods</h4>In this case-control study, a total of 364 noise-exposed workers were enrolled, comprising 156 NIHL cases and 208 normal-hearing controls.Genotyping of SNP loci in the FAS gene was performed using the MassArray system. This evidence concerns the gene FAS and noise induced hearing loss.