Temporal correlation analysis showed progressive inflammatory coupling, with the TNF-alpha of ~ IL6 correlation increasing from r = 0.23 to r = 0.49 over 24 months.<h4>Discussion</h4>Our findings suggest that POAG pathogenesis can be linked to a progressive inflammatory dysregulation, in which other cytokines follow increases in an initial inflammatory cytokine. Here, IL6 is linked to open-angle glaucoma.