HSP90AA1 was identified as a central target, with a docking score of -7.9 kJ/mol.<h4>Conclusion</h4>Peimisine, a metabolite of <i>Fritillariae Cirrhosae Bulbus</i>, demonstrates anti-T2D potential by enhancing glucose uptake and suppressing gluconeogenesis, likely through targeting HSP90AA1, supporting its development as a phytotherapeutic candidate for T2D. The gene discussed is HSP90AA1; the disease is type 2 diabetes mellitus.