It also significantly suppressed the hepatic gene and protein expression of NCOA4, the ferritinophagy biomarker, with enhanced FTH1 hepatic gene and protein expression.<h4>Conclusion</h4>EMPA effectively ameliorated DEXA-induced NASH via reducing liver damage caused by excess iron by restoring the appropriate levels of iron, preventing ferroptosis, restoring lipid homeostasis, reducing oxidative stress, and managing inflammation and fibrosis. This evidence concerns the gene NCOA4 and metabolic dysfunction-associated steatohepatitis.