FTH1 and metabolic dysfunction-associated steatohepatitis: It also significantly suppressed the hepatic gene and protein expression of NCOA4, the ferritinophagy biomarker, with enhanced FTH1 hepatic gene and protein expression.<h4>Conclusion</h4>EMPA effectively ameliorated DEXA-induced NASH via reducing liver damage caused by excess iron by restoring the appropriate levels of iron, preventing ferroptosis, restoring lipid homeostasis, reducing oxidative stress, and managing inflammation and fibrosis.