GLP1R and type 2 diabetes mellitus: Consequently, real-world data evaluating the safety and effectiveness of GLP-1 RAs in this high-risk population remain limited.<h4>Methods</h4>This multicenter retrospective cohort study evaluated adult patients with T2DM and ESRD, including those receiving maintenance hemodialysis, who were prescribed injectable semaglutide between January 2016 and July 2025 at tertiary care centers in Saudi Arabia.