In a Complete Freund's Adjuvant-induced RA rat model, NRG-TPs/HA-MNs significantly reduced paw edema and joint swelling, preserved joint architecture on X-ray imaging, and ELISA analysis indicated significant decreases in inflammatory mediators TNF-α, IL-1β, IL-6, NF-κB, and MMP-3. The gene discussed is IL1B; the disease is rheumatoid arthritis.