WC were also correlated with B cell count, with TG showing a partial mediating effect (Beta [95% CI]: 0.65 [0.44-0.87], with a mediation effect ratio of 30.37%, and 0.02 [0.01-0.02], with a mediation effect ratio of 33.33%).<h4>Conclusion</h4>In health checkups, individuals with normal TG levels, TG plays a significant mediating role in the changes of lymphocyte subpopulations related to abdominal obesity, particularly exerting a positive influence on CD4+ T cells and B cells, with no significant effect on NK cell numbers. This evidence concerns the gene CD4 and Abdominal obesity.