Additionally, there was a shift in microglial responses toward an anti-inflammatory (M2-like) profile, which led to a decrease in pro-inflammatory markers.<h4>Conclusion</h4>ART confers neuroprotection in experimental ischemic stroke by inhibiting NLRP3 inflammasome-associated pyroptosis and modulating microglial inflammatory polarization, supporting its potential as a therapeutic candidate for ischemic stroke. The gene discussed is NLRP3; the disease is ischemic stroke.