NLRP3 and brain ischemia: Atractylodin (ART) shows anti-inflammatory activity, but its neuroprotective potential and mechanistic links to NLRP3 signaling after cerebral ischemia-reperfusion (I/R) injury remain to be defined.<h4>Materials and methods</h4>BV2 microglia were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R), and rats underwent middle cerebral artery occlusion (MCAO) followed by reperfusion.