Single-cell RNA sequencing of murine asthmatic lung and myeloid-cell-specific <i>Tnfsf15</i>-knockout mice (<i>Tnfsf15</i> <sup>Mac-KO</sup>) was performed, and the effects of anti-TL1A interventions were evaluated in allergen-induced asthma models. The gene discussed is TNFSF15; the disease is asthma.