The VB thalamus emerges as a critical locus for ECS-mediated control of seizure generation.<h4>Conclusion</h4>FAAH inhibition represents a mechanistically distinct and circuit-selective strategy to suppress absence seizures, likely through elevation of endogenous AEA and targeted modulation of thalamocortical networks. The gene discussed is FAAH; the disease is Generalized non-motor (absence) seizure.