In addition, the AWGC-specific cachexia subgroup, previously regarded as noncachexia under Fearon's definition, has not been fully characterized.<h4>Methods</h4>We retrospectively analysed 411 Japanese patients with advanced PD-L1-high non-small cell lung cancer who received first-line PD-1/PD-L1 monotherapy or chemoimmunotherapy. This evidence concerns the gene CD274 and Cachexia.