Its expression exhibits tissue specificity and correlates with tumor staging, invasiveness, and pro gnosis.<h4>Results</h4>Piezo1 is upregulated in breast, esophageal, colorectal, glioma, and prostate cancers to promote tumor progression, while its downregulation in lung cancer enhances malignancy.Notably, the Piezo1 channel can be activated by mechanical compression in microcapillaries, subsequently promoting circulating tumor cells to acquire stem cell-like properties through calcium signaling pathways, thereby enhancing their metastatic potential. The gene discussed is PIEZO1; the disease is lung cancer.