113 shared targets were involved in co-infection, and 5 core proteins were obtained through screening, including tumor necrosis factor alpha(TNF-α), interleukin-6(IL-6), interleukin-2(IL-2), interleukin-10(IL-10), and interferon gamma(IFN-γ), which were common inflammatory cytokines. This evidence concerns the gene IL2 and coinfection.