Blood biomarkers, such as plasma neurofilament light chain (pNfL) and glial acidic fibrillary protein (pGFAP), have been associated with (even small) stroke lesions and could support patient selection for neuroimaging and inpatient evaluation in acute vertigo.<h4>Methods</h4>This prospective study included consecutive patients presenting with acute vertigo to a neurological emergency department. Here, GFAP is linked to Stroke.