Leukopenia was significantly associated with age > 65 years (AOR = 2.80; 95% CI: 1.41, 3.36; p = 0.001), pregnancy (AOR = 3.92; 95% CI: 1.76, 8.71; p = 0.04), MTB (AOR = 3.67; 95% CI: 1.89, 7.12; p = 0.001), viral load (AOR = 5.12; 95% CI: 3.01, 8.19; p = 0.046), and CD4+ (AOR = 4.32; 95% CI: 2.02, 7.45). This evidence concerns the gene CD4 and Decreased total leukocyte count.