<h4>Objectives</h4>To investigate the role of the SIRT5-PRDX6 axis during the pathogenesis of sepsis-associated acute kidney injury (SA-AKI).<h4>Methods</h4><i>In vivo</i> and <i>in vitro</i> sepsis models were established to evaluate oxidative stress and inflammatory responses. Here, SIRT5 is linked to acute kidney injury.