Although endoplasmic reticulum metallopeptidase 1 (ERMP1) has been implicated in cancer progression, its specific role, clinical significance, and underlying mechanisms in KIRC remain poorly defined.<h4>Methods</h4>We integrated data from the TCGA, GTEx, and GEO databases to conduct a pan-cancer analysis, aiming to systematically evaluate the expression patterns, genetic alterations, and prognostic value of ERMP1. This evidence concerns the gene ERMP1 and cancer.