In replication analyses, 21 genes showed nominal support in UK Biobank and Alzheimer's Disease Genetics Consortium (ADGC) cohorts, with eight genes (TREM2, ACADS, MFSD12, NUP210L, PIEZO2, PSEN1, SMURF2, AKAP13) supported under identical masks. This evidence concerns the gene MFSD12 and Alzheimer disease.