To complete our evaluation of recognized K<sub>ATP</sub> channel components, we examined the potential role of the regulatory sulfonylurea receptor SUR2 in diazoxide (DZX) cardioprotection in a model of prolonged global myocardial ischemia.<h4>Methods</h4>Mice lacking SUR2 (knockout) and wild-type litter mates (genotype confirmed) were randomly assigned to 90 minutes of global ischemia in a Langendorff model after hypothermic hyperkalemic cardioplegia with or without DZX (100 μM/L) (N = 9-14 per group). The gene discussed is ABCC9; the disease is myocardial ischemia.